منابع مشابه
Synthesis and cytotoxic activity of some derivatives of alkyl piperidine.
Synthesis of novel phenacyl derivatives of alkyl piperidine as cytotoxic agents via simple and single step reaction procedure is going to be reported here. Twelve new compounds were successfully synthesized in moderate yield and in solid form. Their synthesis was confirmed by TLC, melting point, CHN analysis and through different spectral studies such as UV, IR, Mass and proton NMR. The advanta...
متن کاملSynthesis and Evaluation of Novel Phenacyl Based Carboxamide Derivatives of Piperidine as Antihypertensive Agents
SYNTHESIS AND EVALUATION OF NOVEL PHENACYL BASED CARBOXAMIDE DERIVATIVES OF PIPERIDINE AS ANTIHYPERTENSIVE AGENTS Shamim Akhtar, Z S Saify, M Arif, Nousheen Mushtaq, Ahsana Dar, Ashfaq Ahmed Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan, *Department of Pharmacology, HEJ Research Institute of Chemical Sciences, University of Karachi, ...
متن کاملDesign, Synthesis, and Fungicidal Activity of Novel Thiosemicarbazide Derivatives Containing Piperidine Fragments.
In order to discover novel eco-friendly lead compounds for plant pathogenic fungi control, a series of benzaldehyde thiosemicarbazide derivatives with a piperidine moiety have been designed and synthesized. Fungicidal activities of all the synthesized compounds were evaluated in vitro. The results indicated that all the title compounds exhibited moderate to good fungicidal activities. Compound ...
متن کاملDesign, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers.
A series of 2-oxopiperazine, 4-aminomethyl-, 3-amino- and 3-aminomethylpiperidine analogues of DM235 (sunifiram) and MN19 (sapunifiram), two previously reported potent cognition-enhancers, have been synthesized and tested in the mouse passive-avoidance test. The compounds display minimal effective doses in the range 0.3-10mg/kg. Although the new substances do not show improved activity when com...
متن کاملA facile aminocyclization for the synthesis of pyrrolidine and piperidine derivatives.
Bromination of an isolated double bond followed by aminocyclization furnishes a highly stereoselective protocol for the intramolecular formation of pyrrolidine and piperidine ring containing subunits that are presented in numerous biologically active natural products.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1956
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.76.8_968